ATX-304 CAS 1261289-04-6

What Is ATX-304(O-304) ?

ATX-304 (also known as O-304) is an orally active, broad-spectrum activator of AMP-activated protein kinase (AMPK), the key enzyme that regulates cellular energy balance and metabolism.

As a powerful pan-AMPK activator, ATX-304 CAS 1261289-04-6 raw powder is widely used in metabolic, obesity, and fitness research. By stimulating AMPK across multiple tissues, ATX-304 promotes fat oxidation, improves glucose metabolism, and enhances mitochondrial energy expenditure.

Because of these properties, ATX-304 has become a valuable compound in research related to:

• Type 2 diabetes
• Obesity and fat loss
• Fatty liver disease
• Metabolic syndrome
• Cardiovascular health
• Exercise mimetic studies

 

 

Broad AMPK Activation

Unlike indirect AMPK activators, ATX-304 directly activates AMPK in skeletal muscle, liver, adipose tissue, and cardiovascular tissue. This multi-tissue mechanism makes it attractive for weight-loss and metabolic optimization research.

Increased Energy Expenditure

AMPK activation enhances fatty acid oxidation and mitochondrial respiration, leading to higher caloric burn and improved metabolic efficiency.

Improved Glucose Metabolism

Promotes glucose uptake in muscle

Reduces hepatic glucose output

Enhances insulin sensitivity

These effects are useful for diabetes and metabolic flexibility research.

Reduction of Lipid Accumulation

ATX-304 suppresses lipid synthesis while increasing lipid breakdown in liver and adipose tissue, making it relevant for fatty liver and fat-loss studies.

Cardiovascular & Kidney Protection

AMPK signaling improves endothelial function and reduces oxidative stress in metabolic dysfunction models.

 

 

• Product Name:O-304
• CAS Number: 1261289-04-6
• Chemical Formula: C₁₆H₁₁Cl₂N₃O₂S
• Molecular Weight: ~380.24 g/mol
• Appearance: White to off-white solid powder
• Purity: ≥98% HPLC (research grade)

As a professional ATX-304 CAS 1261289-04-6 Manufacture, we provide high-quality material with full COA, MSDS, and batch traceability

 

 

Compound	Primary Mechanism	Research Focus	Differentiating Factor
ATX-304	Pan-AMPK activator	Metabolism, fat loss, energy expenditure	Direct AMPK activation across tissues
GLP-1 agonists	Appetite & glucose regulation	Weight loss, diabetes	Regulate hunger rather than energy usage
Fat-oxidation peptides (e.g., mitochondrial regulators)	Target specific mitochondrial pathways	Build lean mass/fat loss	More narrow target vs multi-tissue AMPK
Exercise mimetics/AMPK indirect activators (e.g., metformin)	Indirect AMPK activation	Metabolic research	Many lack potency or specificity

ATX-304 stands out for its direct, potent, multi-tissue AMPK activation, making it particularly interesting for research into fat loss, metabolic optimization, and fitness performance.

 

 

Storage (powder): Store at –20 °C, dry and protected from light for long-term stability.

Storage (in solvent): –80 °C for long term, –20 °C for shorter periods.

Usage: Dissolve in DMSO or appropriate solvent

⚠ For research use only (RUO) - not for human, medical, or veterinary use. Several sources note "Not for patients/humans."

Handling: Use standard laboratory PPE; follow institutional biosafety protocols.

Stability: Shelf life of >3 years if stored properly.

 

 

While human safety data is limited, preclinical studies of ATX-304 show metabolic changes consistent with AMPK activation and fat reduction. Side-effect possibilities :

• Elevated energy expenditure may lead to increased food intake or metabolic compensation.
• Mild changes in lipid distribution and liver metabolism
• Because AMPK activation is systemic, off-target metabolic shifts are possible in unmonitored use - underscores "research use only" requirement.

 

 

Q1: What kind of research is ATX-304 best suited for?
A1: ATX-304 is ideal for studies in obesity, fat mass reduction, metabolic health, exercise physiology, mitochondrial function, and energy balance.

Q2: How does ATX-304 relate to fitness and weight-management research?
A2: Since AMPK activation mimics exercise/caloric-restriction pathways, ATX-304 is particularly interesting for fitness scientists exploring fat loss, energy usage, lean mass maintenance, and metabolic adaptation.

Q3: Is ATX-304 approved for human therapeutic use?
A3: No - ATX-304 is for laboratory research only and is not approved for therapeutic or human supplementation.

Q4: What purity/spec verification is available?
A4: Research-grade ATX-304 is available at ≥98% purity, with HPLC/MS verification and COA provided.

Q5: Can ATX-304 be combined with exercise/nutritional interventions in studies?
A5: Yes, many researchers use AMPK activators like ATX-304 in combination designs (exercise + diet + compound) to assess additive effects on metabolism, fat loss, and performance.

 

 

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Buy ATX-304 (CAS 1261289-04-6) ≥98% purity – a powerful pan-AMPK activator for research in fat loss, metabolism, and fitness performance. Trusted supply for metabolic & obesity studies.

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