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What is Palmitoyl Tripeptide-8 Powder CAS 936544-53-5 Skin Soothing
Palmitoyl Tripeptide-8 is an innovative, biomimetic peptide specifically designed to calm and protect sensitive or stressed skin. Formed by coupling Tripeptide-8 (arginine, histidine, phenylalanine) with palmitic acid, this ingredient delivers enhanced skin affinity and penetration, allowing it to work deep within the epidermis and dermis.
|
Prouct name |
Palmitoyl Tripeptide-8 |
|
CAS |
936544-53-5 |
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Form |
Powder |
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Appearance |
White to off-white powder |
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Purity |
≥ 98% |
|
Storage |
Keep sealed, protect from light, store at −20°C |
Improves skin elasticity
It helps improve skin elasticity and firmness, which can be lost due to dryness and aging.
Promotes collagen production
Research data shows it promotes collagen production, which contributes to a more youthful look.
Strengthens skin barrier
It helps strengthen the skin's barrier function, protecting it from environmental damage.
Balances skin
It promotes skin homeostasis and helps balance stressed-out skin.
The anti-allergy and soothing mechanism of Palmitoyl Tripeptide-8 involves its interaction with the melanocortin 1 receptor (MC1-R) and the modulation of inflammatory responses in the skin. Within the skin, certain endogenous neuropeptides possess natural anti-inflammatory activity and play vital roles in inflammatory reactions and immune regulation. One such neuropeptide is α-melanocyte-stimulating hormone (α-MSH), a derivative of proopiomelanocortin (POMC), which exhibits significant regulatory effects on skin immunity and inflammatory responses. α-MSH binds to MC1-R with high affinity, leading to the upregulation of inflammatory cytokines such as IL-1, IL-6, IL-8, and TNF-α. By acting as a highly selective competitive inhibitor of MC1-R, Palmitoyl Tripeptide-8 effectively inhibits the binding of α-MSH to MC1-R, thus exerting anti-inflammatory effects. Palmitoyl Tripeptide-8 reduces the adverse consequences triggered by substance P release, leading to a decrease in the release of inflammatory cytokines (IL-1, IL-8, TNF-α), alleviating vasodilation, preventing and reducing external stimuli irritation, relieving symptoms such as itching, stinging, erythema, and edema, maintaining the normal sensitivity threshold of the skin, and promoting overall skin health. By mimicking the action of α-MSH, Palmitoyl Tripeptide-8 effectively regulates the inflammatory response in the skin, demonstrating its potential as an active ingredient in skincare formulations aimed at addressing various skin concerns. Its ability to modulate MC1-R and inhibit inflammatory cytokine release makes it a valuable component for soothing sensitive and reactive skin, contributing to the maintenance of healthy and balanced skin function.


Palmitoyl Tripeptide-8 offers a range of benefits and applications in skincare due to its ability to reduce skin reactivity, alleviate inflammatory responses, and mitigate neurogenic edema. It is particularly well-suited for the care of sensitive skin, demonstrating efficacy in rapidly alleviating inflammation-related symptoms such as redness, swelling, and discomfort. By diminishing the skin's response to irritants and reducing inflammatory reactions, Palmitoyl Tripeptide-8 supports the maintenance of skin health and comfort. Its capacity to mitigate neurogenic edema contributes to a soothing effect on the skin, providing relief from symptoms of inflammation. These properties make it an ideal ingredient for skincare formulations aimed at addressing the needs of sensitive skin, offering a gentle yet effective approach to calming and nurturing delicate skin types. When incorporated into skincare products, Palmitoyl Tripeptide-8 serves as a valuable component for promoting skin comfort and well-being, making it an essential consideration for individuals seeking relief from inflammatory conditions and desiring a proactive approach to maintaining healthy, balanced skin.
Moisturizing: Palmitoyl Tripeptide-8 can increase the moisture content on the skin's surface, enhance the skin's ability to retain water, and effectively prevent dryness and moisture loss.
Antioxidant: This ingredient has antioxidant properties that neutralize free radicals, reducing oxidative stress on the skin and delaying the aging process.
Anti-inflammatory
Palmitoyl Tripeptide-8 can alleviate skin inflammation, relieve sensitivity and redness, and help improve skin issues such as acne and allergies.
Repairing damage
It is beneficial for repairing damaged skin tissue, accelerating wound healing, reducing scar formation, and promoting skin repair and recovery.
Promoting collagen production
Palmitoyl Tripeptide-8 can inhibit pore cells from producing collagen, improving skin elasticity and firmness, and reducing the appearance of fine lines and wrinkles.


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