
PE-22-28 10mg
PE-22-28 is a synthetic peptide fragment derived from spadin, itself a natural breakdown product of the sortilin/NTSR3 ligand. Recognized for its fast-acting antidepressant and neurotrophic properties, this peptide shows promise in preclinical studies for mood regulation, brain health, and tissue repair.
- Product Introduction
Rapid Antidepressant & Neurotrophic Research Peptide
What is PE-22-28?
PE-22-28 is a synthetic peptide fragment derived from spadin, itself a natural breakdown product of the sortilin/NTSR3 ligand. Recognized for its fast-acting antidepressant and neurotrophic properties, this peptide shows promise in preclinical studies for mood regulation, brain health, and tissue repair.
Normiraws supplies ≥99% purity PE-22-28 peptide in lyophilized powder form, intended exclusively for laboratory and in vitro research purposes.
End-to-End Peptide Production Capabilities
We provide a fully integrated manufacturing process-from solution preparation using stainless steel mixing tanks, sterile filtration via ultrafiltration systems, aseptic filling under laminar flow hoods, to lyophilization under strict temperature and pressure control. This ensures high purity, stability, and sterility of our peptide products, meeting stringent pharmaceutical and biotech industry standards.
Benefits & Uses of PE-22-28 10mg
Antidepressant potential – Supports mood regulation through modulation of TREK-1 potassium channels.
Neurotrophic effects – May stimulate neuronal growth and plasticity.
Cognitive enhancement – Improves learning and memory performance in animal models.
Neuroprotection – May reduce stress-induced neurodegeneration.
Rapid onset of action – Demonstrated faster effects than traditional antidepressants in research studies.
Molecular Structure
Sequence: Gln-Asn-Pro-Arg-Leu-Gly-Asn (short peptide fragment of spadin)
Molecular Formula: C₃₂H₅₄N₁₂O₉
Molecular Weight: ~770.85 g/mol
Form: Lyophilized white powder
Purity: ≥99% (HPLC tested)
Mechanism of Action
PE-22-28 acts primarily as an antagonist of the TREK-1 potassium channel, a key regulator of neuronal excitability. By inhibiting TREK-1, the peptide indirectly enhances neurotransmission and increases levels of brain-derived neurotrophic factor (BDNF). These mechanisms are believed to contribute to its antidepressant, neuroprotective, and tissue repair potential observed in preclinical studies.
Comparison with Similar Products
|
Peptide |
Primary Action |
Research Focus |
Relative Speed of Action |
|
PE-22-28 |
TREK-1 channel antagonist |
Depression, neurogenesis, BDNF |
Fast |
|
Selank |
GABAergic modulation, neuropeptide mimic |
Anxiety, cognitive enhancement |
Moderate |
|
Semax |
ACTH fragment analog |
Neuroprotection, stroke recovery |
Moderate–Fast |
|
Noopept |
Nootropic dipeptide |
Cognitive enhancement |
Slow–Moderate |
PE-22-28 stands out for its rapid antidepressant-like effects and emerging role in tissue repair research.
Storage & Safety
Storage (Lyophilized): -20°C, away from light and moisture.
Storage (Reconstituted): 2–8°C, use within a few weeks.
Form: Lyophilized white powder.
Note: For Research Use Only. Not approved for human consumption.
Possible Side Effects
Mild changes in locomotor activity.
Altered sleep patterns.
Potential headache-like symptoms in rodent studies.
No serious adverse effects have been documented in preclinical research, but safety in humans is unverified.
FAQ – PE-22-28
Conclusion
PE-22-28 is an exciting research peptide with unique rapid-onset antidepressant and neurotrophic properties, acting via TREK-1 channel antagonism. Normiraws offers GMP-grade, ≥99% purity PE-22-28, shipped globally for legitimate research purposes. With our commitment to quality, purity, and reliable supply, researchers can confidently explore the therapeutic potential of this novel peptide.
Our Advantage as PE-22-28 peptide Supplier
-≥99% purity (HPLC tested)
-GMP-certified manufacturing
-Secure packaging & fast worldwide delivery
-Dedicated peptide expertise
-Trusted by laboratories globally
Order PE-22-28 Peptide Today
PE-22-28 10mg is a promising peptide in neuroscience, antidepressant, and tissue repair research. Normichem ensures high-quality, GMP-grade, research-exclusive supply, backed by global logistics and professional support.
Contact us now for PE-22-28 pricing, COA, and bulk order discounts.

Pls feel free to contact Vic for any questions:
Whatsapp:+852 5627 6020
Telegram: normiraws
Email: normiraws@gmail.com
Our Advantages
End-to-End Peptide Production Capabilities
We provide a fully integrated manufacturing process-from solution preparation using stainless steel mixing tanks, sterile filtration via ultrafiltration systems, aseptic filling under laminar flow hoods, to lyophilization under strict temperature and pressure control. This ensures high purity, stability, and sterility of our peptide products, meeting stringent pharmaceutical and biotech industry standards.






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Meta Description
Buy PE-22-28 peptide ≥99% purity from Normiraws. TREK-1 antagonist with rapid antidepressant potential for research. GMP-grade quality & fast worldwide shipping.
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